Publications

Colpitts lab trainees are underlined

  1. Jagoda E, Marnetto D, Senevirathne G, Gonzalez V, Baid K, Montinaro F, Richard D, Falzarano D, LeBlanc EV, Colpitts CC, Banerjee A, Pagani L, Capellini TD (2023) Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals. eLife 12: e71235
  2. Archer SL, Dasgupta A, Chen K-H, Wu D, Baid K, Mamatis JE, Gonzalez V, Read A, Bentley RET, Martin AY, Mewburn JD, Dunham-Snary KJ, Evans GA, Levy G, Jones O, Al-Qazazi R, Ring B, Alizadeh E, Hindmarch CCT, Rossi J, Lima PDA, Falzarano D, Banerjee A and Colpitts CC (2022) SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia. Redox Biology doi: 10.1016/j.redox.2022.102508
  3. Halajian EA, LeBlanc EV, Gee K and Colpitts CC (2022) Activation of TLR4 by viral glycoproteins: A double-edged sword? Front. Microbiol. 13:1007081. doi: 10.3389/fmicb.2022.1007081
  4. LeBlanc EV and Colpitts CC (2022) The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor. Scientific Reports 12: 12899
  5. Mamatis JE, Pellizzari-Delano IE, Gallardo-Flores CE and Colpitts CC (2022) Emerging roles of cyclophilin A in regulating viral cloaking. Front. Microbiol. 13: 82807
  6. Gallardo-Flores CE and Colpitts CC (2021) Cyclophilins and their roles in hepatitis C virus and flavivirus infections: Perspectives for novel antiviral approaches. Pathogens 10(7): 902
  7. LeBlanc EV, Kim Y, Capicciotti CJ and Colpitts CC (2021) Hepatitis C virus glycan-dependent interactions and the potential for novel preventative strategies. Pathogens 10(6): 685
  8. LeBlanc EV and Colpitts CC (2021) SARS-CoV-2 RNA: Exclusive friends and common foes. Cell 184(9): 2276-2278
  9. LeBlanc EV and Colpitts CC (2021) A dual antibody test for accurate surveillance of SARS-CoV-2 exposure rates. Cell Reports Medicine 2(3):100223
  10. Colpitts CC*, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng CF, Bartenschlager R, Selwood D and Towers GJ*. (2020) Hepatitis C virus exploits cyclophilin A to evade PKR. eLife 9:e52237 [*co-corresponding author]
  11. Eller C, Heydmann L, Colpitts CC, El Saghire H, Piccioni F, Jühling F, Mazjoub K, Pons C, Bach C, Lucifora J, Lupberger J, Nassal M, Cowley GS, Fujiwara N, Hsieh SY, Hoshida Y, Felli E, Pessaux P, Sureau C, Schuster C, Root DE, Verrier ER and Baumert TF. (2020) A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. Nat. Comm. 11: 2707
  12. Colpitts CC, Tsai P-L and Zeisel MB. (2020) Hepatitis C virus entry: An intriguingly complex and highly regulated process. Int. J. Mol. Sci. 21: 2091
  13. Olbrich A, Wardemann J, Böhm S, Rother K, Colpitts CC, Wrensch F, Baumert TF, Berg T and Beckert J. (2019) Repertoire and neutralizing activity of antibodies against E2 peptide in patients with spontaneous resolution of hepatitis C. J. Infect. Dis. doi: 10.1093/infdis/jiz274.
  14. Colpitts CC, Tawar RG, Mailly L, Thumann C, Heydmann L, Durand SC, Xiao F, Pessaux P, Zeisel MB and Baumert TF (2018) Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape. Gut doi: 10.1136/gutjnl-2016-312577
  15. Eller C, Heydmann L, Colpitts CC, Verrier ER, Schuster C and Baumert TF (2018) The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses. Cell. Mol. Life Sci.71:3895-3905
  16. Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meulemann P, Colpitts CC, Schang LM, Vondran FWR, Kusuma A, Manns MP, Steinmann E and Pietschmann T (2017) Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry. Antiviral Res. 147:19-28 
  17. Colpitts CC and Baumert TF (2017) SMAD about hepatitis C virus cell entry and liver disease. Gastroenterology 152:21-23 
  18. Colpitts CC and Baumert TF (2017) SCARB1 variants and HCV infection: Host susceptibility is lost in translation. J. Hepatol. doi: 10.1016/j.jhep.2017.04.013 
  19. Colpitts CC, Chung RT and Baumert TF (2017) Entry inhibitors: A perspective for prevention of hepatitis C virus infection in liver transplantation. ACS Infect. Dis. 3:620-623 
  20. Colpitts CC and Baumert TF (2017) Claudins in viral infection: From entry to spread. Pflugers Arch. 469:27-34
  21. Verrier ER#, Colpitts CC#, Bach C, Heydmann L, Zona L, Xiao F, Thumann C, Crouchet E, Gaudin R, Sureau C, Cosset FL, McKeating JA, Pessaux P, Hoshida Y, Schuster C, Zeisel MB and Baumert TF (2016) Solute carrier NTCP regulates innate antiviral immune responses targeting hepatitis C virus infection of hepatocytes. Cell Reports 17:1357-1368 (#co-first author)
  22. Verrier ER, Colpitts CC, Bach C, Heydmann L, Weiss A, Renaud M, Durand SC, Habersetzer F, Durantel D, Abou-Jaoudé G, López Ledesma MM, Felmlee DJ, Soumillon M, Croonenborghs T, Pochet N, Nassal M, Schuster C, Brino L, Sureau C, Zeisel MB and Baumert TF (2016) A targeted functional RNAi screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses. Hepatology 63:35-48 
  23. Colpitts CC and Baumert TF (2016) Cell surface glycans as viral entry factors and antiviral targets. Chapter published in Recent Progress in Glycotherapy Book by Bentham Science 
  24. Verrier ER, Colpitts CC, Schuster C, Zeisel MB and Baumert TF (2016) Cell culture models for the investigation of hepatitis B and D virus infection. Viruses 8pii: E261
  25. Colpitts CC, Lupberger J and Baumert TF (2016) Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis. Proc. Natl. Acad. Sci. USA 113:7298-300 
  26. Colpitts CC and Baumert TF (2016) Addressing the challenges of hepatitis C virus resistance and treatment failure. Viruses doi: 10 3390/v8080226 
  27. Fauvelle C, Colpitts CC, Keck Z, Pierce BG, Foung SKH and Baumert TF (2016) Hepatitis C virus B cell vaccines inducing protective neutralizing antibodies. Expert Rev. Vaccines doi:10 1080/14760584 2016 1194759 
  28. Colpitts CC and Baumert TF (2016) Hepatitis C virus cell entry: A target for novel antiviral strategies to address limitations of direct acting antivirals. Hepatol. Int.10: 741-48 
  29. Verrier ER, Colpitts CC, Sureau C and Baumert TF (2016) Hepatitis B virus receptors and molecular drug targets. Hepatol. Int. 10:567-73 
  30. Tawar RG, Colpitts CC, Timm J, Fehm T, Roggendorf M, Meisel H, Meyer N, Habersetzer F, Cosset FL, Berg T, Zeisel MB and Baumert TF (2015) Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties. Hepatology 62:726-36 
  31. Kusuma A, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T and Steinmann E (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation. Hepatology 62:702-14 
  32. Colpitts CC and Baumert TF (2015) A new HCV cell culture model for the next clinical challenges. Nat. Rev. Gastro. Hepatol. 12:611-13 
  33. Colpitts CC, El-Saghire H, Pochet N, Schuster C and Baumert TF (2015) High-throughput approaches to unravel hepatitis C virus-host interactions. Virus Res. 218: 18-24
  34. Colpitts CC, Verrier ER and Baumert TF (2015) Targeting viral entry for treatment of hepatitis B and C virus infections. ACS Infect. Dis. 1:420-427 
  35. Colpitts CC, Lupberger J, Doerig C and Baumert TF (2015) Host cell kinases and the hepatitis C virus life cycle. Biochim. Biophys. Acta Proteins Proteom. 1854:1657-62 
  36. Colpitts CC, Zeisel MB and Baumert TF (2015) When one receptor closes, another opens: Claudins and the hepatitis C virus E1 glycoprotein. Hepatology 62:991-3 
  37. Tawar RG, Colpitts CC, El-Saghire H, Lupberger J, Zeisel MB and Baumert TF (2015) Claudins and pathogenesis of viral infection. Sem. Cell. Dev. Biol. 42:39-46 
  38. Colpitts CC and Schang LM (2014) A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans. J. Virol. 88:7806-17 
  39. Kusuma A, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJP, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T and Steinmann E (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63:1137-49
  40. Colpitts CC, Ustinov AV, Epand RF, Epand RM, Korshun VA and Schang LM (2013) 5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza, hepatitis C and other enveloped viruses. J. Virol. 87(7): 3640-54
  41. Kim SY, Colpitts CC, Wiedemann G, Jepson C, Rahimi M, Rothwell JR, McInnes AD, Hasebe M, Reski R, Sterenberg BT and Suh D-Y (2013) Physcomitrella PpORS, basal to plant type III polyketide synthases in phylogenetic trees, is a very long chain 2-oxoalkylresorcinol synthase. J. Biol. Chem. 288: 2767-77 
  42. Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedermeyer H, Meuleman P, Pietschmann T and Steinmann E (2011) The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry. Hepatology 54:1947-55
  43. Colpitts CC, Kim SS, Posehn SE, Jepson C, Kim SY, Weidemann G, Reski R, Wee AGH, Douglas CJ and Suh D-Y (2011) PpASCL, a moss homolog of anther-specific chalcone synthase-like enzymes, is a hydroxyalkylpyrone synthase involved in an evolutionarily conserved sporopollenin biosynthesis pathway. New Phytol. 192:855-68
  44. St Vincent MR, Colpitts CC, Ustinov AV, Muqadas M, Joyce MA, Barsby NL, Epand RF, Epand RM, Khramyshev SA, Valueva OA, Korshun VA, Tyrrell DLJ and Schang LM (2010) Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses. Proc. Natl. Acad. Sci. USA 107:17339-44
  45. Kim SS, Grienenberger E, Lallemand B, Colpitts CC, Kim SY, Geoffroy P, Heintz D, Krahn D, Kaiser M, Kombrink E, Heitz T, Suh D-Y, Legrand M and Douglas CJ (2010) Polyketide synthase A and polyketide synthase B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thaliana. Plant Cell 22: 4045-66
  46. Koduri PK, Gordon GS, Barker EI, Colpitts CC, Ashton NW and Suh D-Y (2010) Genome-wide analysis of the chalcone synthase superfamily genes of Physcomitrella patens. Plant Mol. Biol. 72: 247-63